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Home - Products - GPCR/G Protein - Chemokine Receptor - ML 604086

ML 604086

CAS No. 850330-18-6

ML 604086( ML604086 )

Catalog No. M16173 CAS No. 850330-18-6

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3?uM and 1.0?uM respectively in cellular assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML 604086
  • Note
    Research use only, not for human use.
  • Brief Description
    ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3?uM and 1.0?uM respectively in cellular assays.
  • Description
    ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3?uM and 1.0?uM respectively in cellular assays; displays high selectvity against a panel of 40 GPCRs, only moderately inhibits 5HT1a (30% at 10?uM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:3.0-5.0 kg male and female adult Macaca fascicularis (primate model of asthma)Dosage:1.038 mg/kg Administration:Intravenous infusion Result:Did not effected the Changes in airway resistance and compliance induced by allergen provocation and increasing concentrations of methacholine.
  • Synonyms
    ML604086
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    850330-18-6
  • Formula Weight
    508.637
  • Molecular Formula
    C27H32N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 120 mg/mL (235.93 mM)
  • SMILES
    O=C(NC1=C2C=CC=CC2=C(S(=O)(N[C@H]3[C@H](C)CN(C([C@@H](N)C)=O)CC3)=O)C=C1)C4=CC=CC=C4C
  • Chemical Name
    N-[4-[[[(3R,4R)-1-[(2S)-2-Amino-1-oxopropyl]-3-methyl-4-piperidinyl]amino]sulfonyl]-1-naphthalenyl]-2-methylbenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jenkins TJ, et al. J Med Chem. 2007 Feb 8;50(3):566-84. 2. Wang L, et al. Thorax. 2013 Jun;68(6):506-12.
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